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If they did a more story-centric game centered around the anime or something it would work.
I don't think they would try another straight R/B remake. Not that they wouldn't be that brazen, but I think financially they would view it as too much of a risk.
Also consider that their player-base is getting older and they DO lose fans this way. A lot of their younger crowd doesn't remember R/B because they were too young, but they do remember R/S or D/P, and want to exploit that nostalgia.