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You know, I think that Charizard anon from last thread is onto something.
While OP, Mewtwo Y's biggest weakness is that it can't take down Ray. If she's pocketed by another heal slut, and if the enemy team has a mandatory defender (Defender needed lol) then there's really only room for one or two defenders at most.
Killing Mewtwo is difficult, but if you can chew up the enemy ADC for Ray then you basically cripple their ability to burn down Ray before your team respawns. Failing that, at least you get to significantly improve your teams chance of survivability since they only need to worry about Mewtwo by himself.
So here's the build: Score Weight, Razor Claw, Energy Amp. 4-6 stacks is ideal if not overkill for exterminating squishies, and try to stack crit rate and 6 browns on your emblem build, a bit of movement speed helps too.
>DON'T NEED TO END YOU, I WILL REDUCE EVERYTHING AROUND YOU INTO ASHEN CINDERS