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I'm replaying X right now, no O-Powers, no Exp.Share, no Amie, and battling in set mode, and I've found out it has the same level of difficulty that previous games' main story.
Well, it may actually be a bit easier because Gym Leaders have shit teams for the most part, and the E4 only uses four pokemon, but it's not that big of a deal.
And well you also have access to some OP mega evolutions, but I'm not using any of those