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This, ideally mixed with Peru on the southern areas. I'm posting the Ecuador map only because Poke Galapagos needs to happen.
>subtropical beaches to the northwest and desert areas to the southwest
>mountains, volcanoes and ancient ruins on the central highland region
>caves, rapids and jungle areas on the Eastern region
>Galapagos as post-game content a la Sevii Islands only bigger and with rare evolutionary variants that only exist there
>legendaries: moon legendary on some beach to the west (sea connection), sun legendary on pokemachu pichu (inca connection), earth legendary on a jungle cave, or something. Mythical kept in Galapagos
>communist armed forces for villanous team?
Anyway, this would all be pretty cool, I think, it'd be an extremely varied region. It's sort of like Hoenn on steroids.