Here's a little bit of autism from a phoneposter late to the party:
>way more different game modes like contests and the like that get the same kind of attention and relevance as regular battles>focus on the interaction between trainers and their pokemon, walking outside the pokeball, amie-like interactions in the overworld, stuff like that>more focus on exploring, having ruins, dungeons, cities, forests, all with their own little story lines and lore>legendary pokemon are actually legendary, usually taking an entire 6 pokemon team to bring town, are also nearly impossible to catch>mythicals are actually mythical, showing up and interacting with the world in significant ways once, maybe twice per playthrough if you're lucky>gym leaders, elite 4 and champion have an impact are actually worth their title, having an impact in the world around them>you can choose to become a gym leader and defend the gymAlso what these guys said:
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