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The Team Rocket-Mewtwo fan theory is a cool one but I doubt anyone would've came up with it if it weren't for damn near every adaptation tying the two together. It has some holes if you think about it
>the fossil mons are never implied to be particularly powerful and it's explictly stated that TR wanted to sell them for cash
>why is giovanni rolling around with poison-types if he wants to defeat mewtwo
>they own powerful (in-story) bug-types like scyther and pinsir, why bother with getting ghost mons too?
>TR counter-teaming Mewtwo doesn't imply they were involved in its creation, they clearly have a way of knowing shit they shouldn't like the Master Ball which was supposed to be a secret
That being said it doesn't matter all that much because the idea of Mewtwo = TR is in just about every other adaptation and is so burned into the idea of the fandom that it may as well be canon now, especially since LGPE itself nodded to it