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>young boy and girl from Pewter City
>they happen to be looking for their first Pokemon in the same place at the same time
>Girl spots a cute Jigglypuff, boy has his eye on a cool looking Mankey
>Throw Pokeballs at the same time, they ricochet in mid air and they both end up catching the wrong Pokemon
>both are (understandably) annoyed at first but their new partner grows on them over time
>from there they kinda do the generic Ash thing and travel from region to region challenging the League, except they actually age and develop over time and end up much different adults than they started as kids