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Game Freak seems to have been winding up to bring Mewtwo back into the spotlight for a while now:
A few small references in the movies or anime (mostly enigmatic clips in the intros)
Game events to get Mewtwo
TCG Specials (New cards, Tin, Collectors pack)
A new form
A new movie
I think Smash Bros. is going to be a part of all this hype.
It's been a long time since I was the target demographic for Pokemon. I just hope the Pokemon kids of today like Mewtwo as much as I did, though they will likely never know him as the vengeful Frankenstein-esque villain I was so impressed by.