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One of the most glaring issues is that the Pokemon world seems designed with stairs, long-distance walking, and poor public transportation in mind. There seems to be the implication that a decent amount of people will travel using their Pokemon. However, if you're a plus-size body type, this can severely limit the amount of Pokemon that you can use for transportation purposes. And this is ignoring the need to use those Pokemon in the first place. If you're a Rock type trainer, for example, there aren't many Rock type Pokemon that can fly or move fast as well as carry you. Your mobility options would be severely lessened. And if this were to be in a warm weather region like, say, Hoenn, you would just end up tired and sweaty most of the time.