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>anime Serena is friendly, loyal, and loves Ash unconditionally as not just a long time friend, but his greatest fan
>in-game Serena is jealous, bitter, and doesn't take defeat well. She understands when to set her pettiness aside for the greater good (defeating Team Flare), but she remains in your shadow and it eats away at her
I prefer in-game Serena, personally. It's a unique and wholly believable personality. Anime Serena is just another generic female that tags along with Ash and while also remaining in his shadow, is perfectly content with it.
