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My friend only spoofed locally until a few weeks ago when he heard Niantic was giving out perm bans. He used Nox. He didn't get banned.
Key is that you won't get banned when you spoof with caution. No one at Niantic is going to check on what fucking device you played and shit. If you spoofed carefully, only within humanly trustable range, you're fine and you will never get banned. I'd be more careful right now though, since they're actually having their eyes on cheaters now. Back then (month ago) it was no problem.