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Alright, so let me predict how this is going to go down.
In the anime canon, there are two Mewtwos. The latest movie features a more feminine Mewtwo created by a different team of scientists, and she possesses the power to go into the Y form for small amounts of time.
This leaves one wondering what is going to happen to the older, masculine Mewtwo of the first movie, whose personality is typically used in most depictions of the Pokemon. Does the advent of a new Mewtwo mean that the importance of the old one will be phased out, or even decanonized?
I predict that the masculine Mewtwo of the past will be reintroduced, likely through some form of anime special, and granted the ability to go into the new X form. Perhaps he will even meet and interact with the new Mewtwo.