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I wonder how many Nuzlockes have ended to Ghetsis. Krookodile was one shotted by Focus Blast, Whimsicott was one shotted by Fire Blast, and then I had to heal my Gothitelle every turn to get him to Struggle to death. Then I died to Wild Charge on Swanna and crit Head Charge on Gothitelle. The last two died before the battle but they fully heal your Pokemon before and after the N fight.
He has to be one of the hardest fights in the series, if not the hardest. I got done Nuzlockeing Platinum recently and Cynthia didn't give me nearly as much trouble.