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Pokemon Rust (tentative name). New region based on Hong Kong, filled with urban cities everywhere but with some divides between them similar to alola. There is only one version, however a few pokemon are randomized on each cartridge to not appear, keeping the necessary trade mechanic.
The region consists entirely of 150 new pokemon, BW style, every single one of them being HK forms of existing ones. This is justified by the region being a major international hub, they all have the common theme of being adapted to its highly urban life.
As the name implies, the overall game would be slightly more mature; nothing edgy, just not specifically aimed at kids (proper marketing would be needed to make that clear). There would be no villain planning on destroying the world or anything outlandish; you could encounter the local triad giving you shit at different points in the game, and help the police in taking them down. I'm not sure how you could make it different from Team Rocket.
Being a heavily business-oriented region, a fun gimmick would be giving a more important role to pokedollars, so that the player never gets the impression of having too much useless money like in every other game. Pokemon centers or story-essential items would cost money, or unlocking whole areas with other pokemon, customization options, etc.
Haven't thought much more than that. I just want something fucking NEW.