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Oak is dead, Blue has taken his place, leaving the Viridian Gym for his sister training bug pokemon. Her being the newest of the gymleaders she's not fit to be the 8th of them, Blaine has taken that position.
Speaking of Blaine he's moved his gym back, this time it's right into the volcano mountain.
Red has returned, and left for the Unova World Championship, Reds now has a little brother.
Brock has traveled to Sinnoh to work for Byron, some random guy took his place.
Sabrina has one battle with the player before she leaves for pokewood and gives the position as city gym leader back to Kiyo
The radio tower has had some strange events caused by disturbing the resting pokemons tombs.
There are no more Snorlax in the wild, Ethan caught the last one, though the Safari Zone has been reopened as a habitat/photo safari where one might see some.
The slugma that appeared in gen2/4 have multiplied quickly, now covering not only the cycling road but also Fuschia and R19.