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The humans in OUR WORLD are mostly fucked, but we know it's very possible to become combat-efficient against and with pokemon.
Gym Leader Drayden fucking WRESTLES with his DRAGONS in order to toughen THEM up. I think it's safe to say that when you can suplex a Salemence, Haxorous, and Hydreigon on a dime, you're fit enough to faint a few 'mons and others with the proper training to do the same.
And Drayden is AN OLD MAN (albeit a very badass one). A young-blooded SOLDIER like Lt. Surge could probably tango and hold his own against several 'mons.
All told, a human race that grew up and evolved with pokemon is a human race that knows how to take pokemon down (although diplomacy is preferred over force, which is why you don't have a lot of Nigglets creating magnitude 10.8 earthquakes all around and Larvitars eating Mt. Silver on a regular basis.
In other words, humans in the pokemon world have evolved with the capabilities to deal with pokemon because of natural selection+technology.
