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Kanto is pretty cool and has nice diversity (caves, seas, forests, safari...), but it's bland too.
Johto is a solid Kanto expansion, but it is very, very small.
Hoenn has nice map design in general, but it has way too much water.
Sinnoh is vast and flavorful, but it's too gray and tries to be too serious.
Unova is very similar to Kanto, but it's really linear (and the lack of safari hurts).
All regions have their goods and bads.