As bullshit and tedious as they have become, I'm sure a lot of you have moments in the anime where Jessie, James and Meowth really amused or moved you.

What is a moment that stands out for you?

For me it was in Pokémon 2000 where they decided to help Ash by letting go of Lugia's leg so they could get away faster from the legendary bird trio.
When I saw this in the movie theatre as a kid, I seriously thought they were gonna die and had made the ultimate sacrifice for the greater good. Then they didn't, so meh.

Let's not forget all their snappy dialogue which is ongoing IMO.