Let's see. Due to the Colress reference, we know that this would have to be a sequel, because a standard remake won't work in the current position of the timeline. So where are we going:
>Kanto
Due to the Gen 1 pandering, and the Origins, very likely.
>Johto
Last time we revisited a region, it was Johto, so not likely.
>Hoenn
Sequel to an over-a-decade old game? We already have so many Hoenn Pokemon/Mega's in Kalos, so revisiting Hoenn wouldn't give us anything new. Unlikely, despite all the HOEEN CONFIRMED bullshit.
>Sinnoh
Game Freak's waifu is yet to be found in Gen 6. This is reason enough for them to bring her back.
>Unova
Too early since Gen 5
>New Region
Possible, but why?
