>>15035892Aim to get a set of all useful natures (all except the +Def-SpDef, +SpDef-Def and neutral ones), and as many 3+ IVs as you possibly can from a Ditto Safari.
Use Everstone to guarantee nature on babies.
Breed for better babies, who will become better parents for future babies.
You should settle on a baby with no less than 4 perfect IVs in relevant stats. 5 is better. Few Pokemon rarely benefit from an actual set of 6 (mixed attackers).
Breed for the rest of your life. Don't forget to first breed egg moves and then make sure the parents don't forget it as they level up in daycare.
It's easier to start with other Safari mons + Safari Ditto, due to guaranteed 2-4 IVs between them, allowing for efficient use of Destiny Knot.
Breed for the rest of you life.