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I did one in White recently, it started out mostly frustrating as I just kept ending up with super fragile mons that would die not long after I got them (including a Sassy Darumaka who was the king when at Burgh's gym but died to the Cheren fight on Route 4), as well as ending up with a -Atk Snivy who died before Gym 2 to a fucking Roggenrolla thanks to being piss-weak and being hit by a 5 hit Rock Blast with a CH thrown in.
I also got a shiny Audino, who surprisingly was amazing and lasted most of the game until gym 7. It was nerve-wracking ending up in Nimbasa City with just an Audino and a Maractus, though, and catching a Trubbish only helped somewhat (R.I.P, you almost made it to the Elite Four).
Lategame was amazing, I caught Golurk AND Beartic (I was playing in "Winter"), two cool guys I've wanted to use for a while, and they survived the rest of the game. Sawsbuck and the lame natured Sassy Durant were really useful too for the Elite Four and especially Ghetsis.
It's a different way of playing and I did have a lot of bad luck with natures and what I ended up with early on, making it more frustrating than needed at times, but I'd do it again some day.
>mfw I write an essay