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it's not like I like dragonball over pokemon, but it's pretty much objective that the characters in dragonball are just insanely powerful, to the point that past a certain point they begin being careful not to blow up the planet they are fighting on... honestly, the more I watch anime the more I wonder if, put, in the same world like in a shitty fanfiction, anything would be able to beat DBZ characters at all. maybe Gurren Lagann got close to that, at the end they were throwing fucking galaxies at each other, and that's with the help of magical conservation-law-ignoring willpower-powered mechas.
as for Mewtwo, the only good point I've seen so far in this thread is that he has psychic power as in controlling/wiping minds, and that's up for discussion if he can even do that, since trusting anything outside the game or even the pokedex entry results in ridiculous jokes most of the time