I'd like to see a region south of Unova, based on southern New Jersey down through Pennsylvania, Delaware and Maryland, and on to D.C. and maybe Virginia. There's a good variance of climates in that area, a wide range from urban to rural, mountains, rivers, oceans, and some pretty distinctive cities. Could be interesting.
Won't happen, though. I think it'll be a couple more generations before another American-based one, if ever.
