You pay real money to buy pokéballs
Your results in online battles are immediately posted to your Facebook, along with your trade activity (you're not allowed to play online without linking your facebook account)
Protagonist designs even worse than ORAS
All music in the game is just this played at different speeds and pitches:
http://www.youtube.com/watch?v=0kcF7E69C6Q&feature=relmfuAll pokémon now have their anime cries
1 new pokémon, which is a middle stage pokémon in between Riolu and Lucario
You receive a mild electric shock every time you press a button
No running shoes
The game runs at 1fps