>>23021369The Kanto and Johto city layouts are actually pretty distinct, even if the sprites and tiles used for them are not. Kanto cities were all structured very differently; like Fuscia, Cinnabar, and Celadon. Johto cities were simpler in layout (usually looking very rectangular with similar building placements), but compensated by including landmarks at each location such as the Sprout, Radio, and Burned towers or the lighthouse and slopoke well.
4th gen cities have probably been the least distinct so far, but I only say that because a lot of them mirrored cities in the older games. Look at how similar Jubilife was to Rustboro. In its own game, it's pretty easy to tell the cities apart.