>>24769440Basically, it's about the context. This is a webcomic (a pretty bad one) about videogame and humor. except the author occasionally draws himself in it as well as his closest friends and makes an entire arc out of incredibly cringeworthy drama.
This one became famous because it's his girlfriend having a miscarriage. Since the four panels put together are so easy to identify, people make edits out of stuff to imitate it.
It's been so overdone by now that only the most subtle stuff gets any laughs though.