>>26717622They could make it so that it can only use items as if they were berries: I.e. waits until it has the condition before using a burn heal, waits until it is low on HP before using a hyper potion, waits until it's confused before playing the flute, etc.
It could also cause some fun interactions with unusual hold-able items, like trying to catch an enemy pokemon at low health with a held pokeball, using a held poke-toy to force a switch (triggered, probably, by landing a not very effective hit) or using an escape rope to switch itself out (after eating a critical or SE hit, or when it's health gets low.)
Or just chugging that Dire Hit at the start of combat like it was an energy shake.