Kanto- All right? It was okay in HG/SS. It's not great, but it's not bad either. It's just "okay".
Johto- It's the comfiest region (IMO), and is probably the least advanced region. It's got lots of cool places, and it's only big problem is the odd leveling and Pokemon Distribution.
Hoenn- Hoenn was easily the hardest for me to grade, but I decided to take the original games in more than ORAS. It's got lots of good Pokemon, good music, and good towns. However, the region can get a bit dull, and Hoenn doesn't really have anything special, besides the Battle Frontier, which was not in ORAS. I feel like 2.5 is too low, but Hoenn doesn't deserve over a 3.
Sinnoh is an amazing region. (Almost) every town is memorable, and it has some of the best music, Pokemon, and characters. I really don't know any big flaws, besides DP, but Platinum really fixed them up.
Unova- I feel like the creators really spent their time on making an amazing region. Every area is memorable, and all the characters are important. It's really just a great region.
Kalos- Easily the worst region. It feels like it was just made to pander. Megas were mostly a gimmick and were only needed on about half of the ones the gave them to, even though regular evolutions would've been better. Two Mega Charizards and Mewtwos, and all the handholding made Kalos terrible. The region is dull, and almost every location is forgettable, besides Lumiose (a failed idea) and a few others. The (very few) new Pokemon are distributed terribly, and mostly found on one route at a very low chance. Characters are there for little reason, and Kalos is overall a terrible region.
Alola- Looks okay for now.