I think other people are tired of the mega cities some of the newer games do, but I would like to urbanize the mid-game area to give Kanto more flavour. Basically, take Saffron City and the four cities/towns adjacent to it, Cerulean, Vermilion, Celadon, and Lavender, and make them all part of one big metropolis that covers the entirety of central Kanto. You can still keep the original names as districts or whatever, or still call them separate cities but have the design connect them as an urban core.
The four routes connecting the five of them are all very short as is, but I'm not suggesting removing them. Although it would all be one big city, I would still want the same or similar blockades in place, the same progression, and the equivalent of "routes" between them, with trainers and wild encounters. The route between Saffron and Vermilion for example strikes me as something that could be turned into a park within the city.
Also expanding each of them in size and theme, like
>>33447466 suggests with making Celadon more neon. I also agree about making Cinnabar a much bigger island. I hesitate to say just make everything bigger, but some places need it. I would still like Pallet, Viridian, and Pewter to be kind of dinky compared to the super city, each getting a bit bigger as you move toward the center of the region.