Fertile ones and the ones with the biggest breasts, hips, thighs, and asses with a pretty face and a small waist. It's important not just that the breasts, hips, thighs and asses are as big as can be, but also that they are big in proportion to their waist. The bigger the discrepancy the better. Huge plus but optional: tight waist, good personality, and well dressed (well meaning little/tight clothes.)
I shouldn't have to say this but obviously everything I named is the objective hard-wiring that normal male brains should be attracted to. Pokemon doesn't have many of these so it makes it easy, plus I'll narrow it down even further and make it main games only
Gen 1
Lorelei
Gen 2
Clair
Gen 3
Flannery
Gen 4
Ariana (HGSS)
Gen 5
Skyla
Gen 6
Shelly (ORAS)
Gen 7
Wicke
And to rate them
Lorelei>Wicke>Ariana>Skyla>Shelly>Clair>Flannery
I'd like to reiterate here that very few women in this franchise on the whole are even busty, let alone in the huge breast category.
Special shoutouts to Professor Juniper, Alexa, Zinnia, Whitney, Karen, Shelly (Ruby/Sapphire,) Dahlia, Bianca, and especially Olivia
Jessie would also get a shoutout because she's in Yellow, however we don't know how closely she resembles her anime counterpart
in fact almost every single female pokemon character has a larger bust outside of the games. the manga and the anime and even spinoff games give them much heavier chests than in the offical artwork from the games. sad really