>>34720730RSE still feels more memes that the past few gens. Between the OP image, Fug, every other weather trio edit and comic, Regi = Reggie, Hoenn Confirmed, trumpets, water, and probably some other stuff in forgetting, it's really stood the test of time.
I'd say only Gen I beats it, but a lot of the Gen I memes can also be applied to the franchise in general.