Pallet Town has been sunk beneath the ocean because the Cinnabar Volcano erupted again, causing an earthquake, sending a tsunami right at Pallet Town.

Pallet Town and Route 1 is under water, but Cinnabar Island is now larger.

You play as a different trainer, the female looks like Yellow from the manga series.The male character is completely new, but has moved from Unova.

The starting town is a new city that is inspired by Yokohama.

Other regions will open up over time with DLC.

Red, Blue and Green all play a role in the games.

There are a number of new Kantoian Forms.

The evil team are evil alternates of all the heroes of different universes of the pokemon series wanting to control the time lines.

There are 50 new pokemon currently, but more will be release with every region, not always being the same amount.

The image with Lapras and the Eevee on the trainer's head is real, but it isn't where you may think.

Sevi Islands makes a return. Johto is slated to come out a few month after the original release which is still undermined.

Most regions will have new towns and areas that may or may not be from the anime or other games.

Seasons makes a returns as well as the addition of holiday events and festivals.

There is also more customization for your character.

Orre and Ryme City are mentioned. Ryme City is stated to be in a region west of Unova where Seven Sacred Lakes meet.