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For in game use? well, how early you get them does matter.
1. Choose Bulbasaur. It's good against the first 4 gyms.
2. Catch a Spearow early. It will take some time but Drill Peck is a beastly move gen1.
3. Diglet can be caught relatively early and is also quite beastly with moves like Dig (unlimited escape ropes out of battle!) and Slash. Also, it completely neuters the third gym.
4. Tentacool/Tentacruel are really good gen1. Very good special stat, fast speed, and learns Wrap. Wrap was really good back then.
5. You need a Psychic but Abra is a pain in the ass to catch and doesn't learn anything useful until it evolves. There's a Trade spot for Jynx in Cerulean city, Jynx is awesome and makes Sabrina, Tem Rocket, and most the Elite 4 her bitch. So Jynx goes here. You can trade Poliwhirl for it, so train one of those until you get to Cerulean. Poliwhirl is okay on its own ,it won't be dead weight since Water Gun fucks up all those damn Hikers in the Rock Tunnel.
6. This one's a wild card since most of the bases are covered now. Solid options are Jolteon (give it the Thunderbolt or Thunder TM), Nidoking, Snorlax, and Clefable. I'd personally say Snorlax, but that's just me.
