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When you deal with 3D models, you generally don't go strictly with one or the other. You draw up concept art, make a rough model, modify the model so it looks good from as many angles as possible, then draw the official art to reflect any changes the model had to go through. Faces in particular tend to be an issue. They can look good from the front and side, but look completely fucked up from a 3/4 angle.
