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>No NatDex & no Sinnoh regional variants. Even some Gen I - III Pokémon are removed regardless if they were in the Sinnohdex previously or not, like Unown.
>Mt. Coronet and The Underground are combined into one giant, open, cavernous "Wild Area". Camp replaces Secret Bases.
>PalPark is turned into a second, mini-Wild Area. All of the few implemented Gen V and later Pokémon are found there.
>Pokétch is replaced by the Rotom Phone. No Rotom Watch reskin, new Pokétch model with Rotom Phone connectivity, or anything like that.
>All patches of soil used to grow berries and all honey trees are replaced by shakable berry trees. Munchlax still has its specific location gimmick.
>The Game Corner, Great Marsh, and Contest Hall are copypastes of their ORAS counterparts. For the Contest Hall, you get a Cosplay Eevee as soon as you enter to use to cheese the entire mini-game.
>The following places are removed: Global Terminal, Floaroma Meadow, Fuego Ironworks, Wayward Cave, Amity Square, Solaceon Ruins, Maniac Tunnel, Trophy Garden, Iron Island, and all post-game and event exclusive areas.
>The Battle Tower is now located in Jubilife where the Global Terminal was. Acts the same as SS.
>Seals, Accessories, Decorations, and just about any other flavor fillers not in SS outside of ORAS-level contests are gone.
>No poffins, just curry. Flavored curry boosts contest conditions.
>Cynthia and Barry will be forced upon you in cutscenes way more often with the former never shutting up about her Lucario, much to the dismay of Garchomp fans.
>Giratina is a mandatory capture at the climax. Post-game is 2-hour long story where you are given Uxie, Mesprit, and Azelf and the opportunity to catch Dialga/Palkia and Arceus. All other legendaries are raid events to further push GO.
>You might get some new Gigantamax forms if you're lucky.
>More simplification of the game overall, etc.