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They're canon, just not part of a connected region i.e. you'd have to take a plane or long distance boat trip versus Kanto/Johto, where you can literally walk to the other one.
>Due to the fact that these regions are said to be farther away from the others, some of them have a completely different theme, and Orre, Unova, Kalos, Alola, and Galar are based on areas outside of Japan (the basis of the rest of the nation), it is unknown whether or not they are part of the same nation. These regions have several ties with the confirmed regions.
