>>45617788Natures, Evs, and IVs are all for postgame. You don't really NEED that stuff for the main game, but it of course helps, and probably is necessary for anything like a Nuzlocke.
The reasons that this game is difficult to nuzlocke are different than standard difficulty.
The classic reason is Motherfuck.
Motherfuck is a random encounter that can start showing up in later game caves. All Motherfuck have Shadow Tag, a "special" Focus Sash that can't be stolen, and a moveset with only Spore, Perish Song, Destiny Bond, and Explosion. They have no other level up movs, so will only know those 4 moves. They also have a catch rate lower than a lot of legendaries, so hurling balls isn't a good strategy either.
Motherfucks will fuck you up, man. They're an annoyance on normal game modes, you just use a Revive and move on with your life, but on Nuzlockes, they can outright kill frailer pokemon with Explosion, or Spore+Perish Song+Destiny Bond others.
There's other reasons too, but those stand out.