Yes, but neither are actually mainstream.
2b2t is only known because of that one youtuber who does videos on the history of the server and I doubt any of the viewers actually play on the server.
Same with Clover. The only thing that's really mainstream is the dead Regis, and that's just because they're a neat concept. I doubt most of the people interested in them are interested in a game full of 4chan humor they won't get.