>>46220200Mewtwo, because it's built up with the journals in the Pokémon Mansion, but then the time you spend going through Viridian's gym, Victory Road and the Pokémon League are enough to take it off your mind before you explore Cerulean Cave, find Mewtwo in the deepest point and remember oh shit I read about this monster before, in the wrecked house on Cinnabar.
Ho-Oh because its built up by legends surrounding the two towers of Ecruteak being the talk of the town, and the Bell Tower itself feels sacred but kind of foreboding as well, and you know the saying that Ho-Oh occasionally comes to roost on the top, but you don't know that it's actually going to be there when you climb it.