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Between Toxapex and Ghost-types (due to the Pursuit removal), Blaziken struggles with 4MSS since it needs KO for Ghosts and Thunder Punch for Toxapex.
In Gen 5, nothing could handle Flare Blitz/High Jump Kick.
In Gen 6, Fairy types ate Fighting moves but the Mega was strong enough to muscle through them.
In Gen 7, Electrium-Z allowed Blaziken to muscle through bulky Water resists like Toxapex.
