Did you know? Lopunny were hand-crafted by Arceus Herself to be perfect sexual partners for humans? It's been discovered their extremely frequent heat cycles are in fact similar in time scale to human women's menstruation cycles and while their desire to mate drives them to seek out any suitable male, invariably their increased vigorousness during coupling leads to exhaustion of their partners and the Lopunny being left unable to satisfy their needs - a problem not encountered when a Lopunny selects a human, due to the increased stamina potential of human males.
And that's not the end of it, their biological development has left them with both narrower vaginal passages than the overall average sized passage yet led to more muscly, stronger-walled passages than the average, meaning that even the most unimpressive male endowment will almost-certainly be more than enough to give his partner an incredibly memorable time and satisfying encounter. And even if the Lopunny is impregnated during every cycle, with the natural resistance of pokémon to injury and the like, she can carry the kitten to term and give birth and her vaginal passages will still stay as tight as the day she evolved. This heady combination of super elasticity and dense musculature has given rise to an almost prehensile-like ability of the vaginal walls to mould to every groove and ridge of their lover's phallus completely, with many female Lopunny eventually shunning males of all pokémon species in favour of sating their biological urges and desires in the arms of their trainers. Unsubstantiated reports surface every so often from anonymous males stating they similarly have stopped seeking human couplings, citing Lopunny's clear superiority over human women as reason.