>>49108167Gen 1 isn't that bad. The biggest issues you'll likely run into are:
Very little in-game info. Later games tell you the basics of what an attack does, how powerful it is, etc. when your Pokemon wants to learn it. Gen 1 just tells you the name of the attack. So either keep Bulbapedia open on your phone or get ready to memorize a lot of stuff.
Physical/special is based on types. Stuff like normal and fighting pit your attack stat against the opponent's defense. Stuff like water or fire pit your special against their special. It's the type of the attack that matters, not the type of the Pokemon.
Exp All can be useful for training low level stuff when you're fighting all high level trainers, but can be insanely annoying. In gen 1 it announces the exp every single fucking Pokemon gains every damn time and you have to scroll through all of it. I just got out of a battle with a fisherman with 6 Magikarp and after defeating every one of them I had to click through dialog about each of my Pokemon gaining like 5 exp.
Don't learn or use Focus Energy. It's supposed to get you more crits but due to a bug it boosts the chances so much that it wraps around and gets you almost no crits.
Careful when giving low level pokes a bunch of exp. If they grow more than 1 level at a time and that level was when they would learn a move, they won't learn the move. Since there's no move relearner in Kanto, it will never get that move, period.
Similarly, be careful when teaching HM moves. They cannot be forgotten since there's no move deleter in Kanto. (You can delete HM moves through a programming oversight though: put the HM move you want to delete first in the list (select reorders moves during a battle), make sure it's 1 level shy of learning a new move, then put it in day care until it gains that level. The new move will overwrite what's first even if it's an HM move.)
Don't fight wild Bellsprouts or anything else that knows Wrap. Just run. The exp they give isn't worth it.