I could dig it.
>Legendary trio based off of Zeus, Poseidon, and Hades
>Professor that's just Leonardo Da Vinci
>Evil team could be mobsters, Romans, or fuckers based off of the venetian masquerade
>Fighting type Pokemon based off of Heracles that exists as the natural predator for Hydreigon
>Regional evolution for Mawile based off of Medusa
>A fucking minotaur (that's also a matador)
>Atlantis as a special location in-game
>Battle Tower is the Colossus of Rhodes and the Frontier Brains inside of it are a sentai team
Lord knows what the gimmick would be though.