>>52631586If we don't include legendaries out of the hands of the region, Galar and Alola most likely stand the best chance to fight. Galar keeps Eternatus as a living battery and turning it into a weapon seems like not much of an issue.
Alola has the tech to summon wormholes that drop violent threats into the unsuspecting public. They even have access to the ultra recon squad which own their own box legend to summon wormholes.
Unova could use Neo Plasma's weaponry to freeze whole cities again so they have some fight left.
Kalos has access to its death lazer but that depends on if they can get the box legend to cooperate.
Pretty much all the spinoff regions have nothing to stand on for power scaling except the Mystery Dungeon regions whose rescue teams casually beat up legendaries.