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>take the periodic table and pick an existing pokemon for each to make the dex
>pull one or two cycles of items (most items are redundant, by design ie: Full Heals, Lum Berry, Lava Cookie) and exclude the rest
>make a 6 or 7 town region connected by quest lines, no gyms
This was after a few minutes of thought, with more time I can make a game that gamefreak would have ceased and desisted.