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A romhack that let you influence the ecology would be interesting. There's a lot of design space that I don't think anyone's done
>Releasing Pokemon to increase encounter rate
>defeating or catching an excess of one type reduces or removes it from the pool
>predator/prey interactions; if you remove a predator, the prey species population explodes. if you remove prey the predator species also declines, but berry trees produce way more fruit
>Species from neighbouring routes invading if the local population gets too small to defend its territory
Could be neat