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Part of what makes Irys look a bit off-putting to people is her palette is for some reason kind of darkened overall on RGB, like she's always in a dim room, compared to others looking like they're in a lit room. The eye catches it and the brain subconsciously notices it's different, thus even beyond the details like the nose or design quirks something about it feels just "off." The worst part actually is the teeth IMO - they turn kind of gray because of it and that looks naturally very-very off.
I'd noticed Irys seemed to correct her tone a bit before but, it's definitely off again this stream, wonder why. Maybe because it needed some extra processing or something to do the projector trick for this karaoke? I'm not sure what she tweaked before but it does make a significant difference.