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I did some research on the root cause of Reimu's yellow fever and I have some interesting findings to share.
It's all about the cock.
The average dick size in Colombia is 17 centimetres, the average depth of the vagina is 16 centimetres deep but that's data taken from U.S. and British medical research. Reimu being a very small Latina must have a smaller vaginal depth, let's be generous and assume 12 centimetres.
My theory is that Reimu's first boyfriend's cock was too big and too thick for her small pussy. There's also the added factor of her disposition as a crybaby; she must have wept and cried and had an awful time ruining the coitus for herself and her boyfriend thus adding a further embarrassment and shame.
This led to Reimu developing an aversion to big cocks and preferring men with smaller cocks like Asian men and Vox (self described as having a little cock).
On another note it can be assumed Pomu experienced a similar situation however she was determined to take a cock no matter how big it is.
This is why Pomu is a size queen; she pridesherself in being able to beat the cock and not failing and crying.