>>89194440The major differences are that you can play the remake above 60 FPS without the game breaking, the weapons have all been rebalanced so now the Flamethrower is actually great instead of being a worthless piece of shit tool, and now Isaac talks during specific scenes where it makes sense for him to talk. And like the other anon said, you can travel back and forth between sections of the ship freely if you want to head back to open up security doors and do optional side quest things.
We all know she's gonna use the Ripper and Plasma Cutter (because chat won't shut the fuck up about them), but I hope she doesn't shy away from using the other weapons too.