After a little bit of pruning, I've compiled your suggestions into a Cards Against Humanity deck, compatible with the "Many Decks" version of the game (as Cardcast for Pretend You're Xyzzy bit the dust). I have kept some references to the users but decided to prune answers that were just usernames; something like "Cypher's Thinkpad" is okay, "Cypherposter" is not.
I'm sure some of the prompts are more viable/funnier than others, and there might still be things missing from the deck, but we should give it a go and see what sticks.
Last but not least: a big thank you to everyone who participated!
Anyways, here is the deck so far:
https://decks.rereadgames.com/decks/N9G08 